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And that's what's hard

The cells were incubated for 5 min at 30C with constant shaking at 400 r.p.m

Doses continue to escalate to 10mg and 12.5mg weekly

CCT-deficient B cells stimulated with LPS triggered early activation of the unfolded protein response (UPR)-mediated splicing of Xbp-1, and impaired class switching, reducing antigen-specific IgG1 production while increasing IgM secretion upon antigen challenge (104) ( Figure 3 )