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Current therapeutic strategies for OA-BMLs include non-weight-bearing protocols, pharmacological interventions such as diphosphonates (bone resorption inhibitors), prostaglandin I (PGI), and strontium ranelate (SrRan, a bone turnover inhibitor), as well as surgical approaches like bracing, subchondroplasty (bone substitute injection), high tibial osteotomy (HTO), unicompartmental knee arthroplasty (UKA), and total knee arthroplasty (TKA) [23]

DNF-10 is a clinically studied complex of small bioactive peptides derived from Saccharomyces cerevisiae, designed to support healthy satiety signaling through two complementary neuroendocrine mechanisms.*

In conclusion, although the independent use of HGF for diagnosis is controversial, HGF is useful when combined with other diagnostic markers

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