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doi: 10.1002/art.34637 87 ReisBSLeeKFanokMHMascaraqueCAmouryMCohnLBet al

Furthermore, intradermally administered nanoparticles interact intimately with dermal immune cells, such as dendritic cells and macrophages, thereby modulating local immune responses and reducing systemic exposure, which enhances therapeutic efficacy, biocompatibility, and patient safety

Currently, investigators are emphasizing the development of smart nanogels that respond to environmental stimuli, like temperature, pH, or magnetic fields, to acquire controlled and site-specific release of drugs