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Type III SMA has a later onset and better prognosis

eLife 9, e51830

3.4.2 Clinical evidence Despite strong preclinical evidence, clinical data on metformins cardioprotective effects remain limited and somewhat inconsistent

An early study indicated that the thymidylate synthase ( TYMS ) gene 3R/3R variants were more common in Asians [29], and this could affect 5-Fu tolerance