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Orsola-Malpighi Hospital, (11)Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli, (12)Division of Gastroenterology and Hepatology, Foundation Irccs Ca Granda Ospedale Maggiore Policlinico, Milan, Italy, (13)CRC "a

Figure 6 3.8 CB-839 did not improve cytotoxicity in combination with venetoclax, AZD-5991, and ibrutinib in primary CLL lymphocytes We then tested these drug combinations in the primary CLL cells, both in the native condition ( Figure 7A ) and in media supplemented with cytokines (CD40 ligand and interleukin-4) to mimic the microenvironment and maintain viability ( Figure 7B )

Follow-up Repeat broad markers after 6-12 weeks if symptoms change, inflammation is part of the context, or the protocol continues

This was first proved by the study that immunotherapy-activated CD8 + T lymphocytes can induce ferroptosis in cancer cells by downregulating SLC7A11 and SLC3A2, encoding subunits of system X c