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PMID 17606868

The most serious but rare complication is metformin-associated lactic acidosis (MALA), typically occurring in the setting of renal impairment and mechanistically linked to mitochondrial complex I inhibition (Zhou et al., 2001)

The fact that the gut microbiota are key regulators of immune function and inflammatory responses, it is likely that a change in the composition of the gut microbiota during aging plays a role in the gradual activation of the immune system and consequently inflammaging (Prenderville et al., 2015), possibly via an impact on intestinal permeability

1999;399(6738 Supplement):A7A14