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Start slowly, patch test when trying a new topical product, and avoid applying copper peptide products to irritated or broken skin

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While the N-terminal methionine on most proteins also is efficiently removed in most prokaryotes, for some proteins, this prokaryotic removal process is inefficient, depending on the nature of the amino acid to which the N-terminal methionine is covalently linked

Thus, it might be proposed that in the cuprizone model CCL2 modulates an early attraction or activation of microglia to the lesion site, while CCL3 plays an important role in later stages, possibly promoting proliferation or initiation of phagocytosis of myelin debris