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In agreement with this, an increase in complex IV activity has been also observed in rats with NAFLD induced by methionine and choline deficiency and it was hypothesized that complex IV enhancement is an adaptive response to increase energy wastage in order to enhance fatty acid oxidation and limit ROS production (Romestaing et al., 2008)

10.1093/neuonc/nou087 79 OstromQ

Toxicology 318:5968 Gegg ME, Clark JB, Heales SJ (2005) Co-culture of neurones with glutathione deficient astrocytes leads to increased neuronal susceptibility to nitric oxide and increased glutamate-cysteine ligase activity