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Third, clinical efforts should include establishing multicenter FRDA biobanks to validate associations between ferroptosis biomarkers (such as ACSL4 and mitochondrial iron content) and clinical measures including SARA ataxia scores and left ventricular ejection fraction, and conducting combination trials of ferroptosis inhibitors with ironsulfur cluster metabolism regulators to evaluate synergistic improvement in neurologic and cardiac function

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biotin carboxylase MDSC: Myeloid-derived suppressor cells CAFs: Cancer-associated fibroblasts TAM: Tumor-associated macrophages PD-L1: Programmed death-ligand 1 PGE2: Prostaglandin E2 GSH: Glutathione References Karnezis AN, Cho KR, Gilks CB, Pearce CL, Huntsman DG