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ACR (50 mg/kg [8], intraperitoneally (i.p.), 14 days) and two different doses of MEL (10 and 20 mg/kg, i.p., 14 days) [8] were administered to the experimental groups

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Mitochondrial metabolism also contributes to ferroptotic sensitivity through nutrient utilization and bioenergetic rewiring.Glutamine is essential for ferroptosis, and glutamine synthase 2 (GLS2), a key regulator of glutaminolysis, has been demonstrated to promote ferroptosis [90]