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Dutta S, Sengupta P, Roychoudhury S, Chakravarthi S, Wang CW, Slama P (2022) Antioxidant paradox in male infertility: a blind eye on inflammation

More than 20% of patients experienced grade 3 adverse events (AEs), including febrile neutropenia (47%, 23/49), thrombocytopenia (37%, 18/49), leukopenia (25%, 12/49), and anemia (22%, 11/49)

However, excessive caffeine consumption can lead to adverse effects, including addiction, nervousness, irritability, anxiety, tremors, muscle twitching, insomnia, and heart palpitations (160)