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By specifically recognizing lactylation sites and combining this with immunofluorescence staining, it is possible to detect lactylation modifications on target proteins and is available to precise localization within tissues

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Administration of this nanoparticle, combined with the PD-L1 antibody, has polarised the M towards the M1 phenotype, which further leads to a reduction in inflammation, immunosuppressive activity, and pro-tumour signalling by downregulating NF-B and STAT3