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33,34 In cartilage destined to be replaced by bone via endochondral ossification, chondrocytes, typically organized as morphologically discrete domains in growth plates, progressively mature and eventually undergo hypertrophy characterized by COL10A1 (encoding collagen X) expression

Table 2 Antitumor therapeutic strategies targeting glutamine metabolism-related pathways

However, people with the more severe forms of this condition need regular blood transfusions and other treatments, including medicine, folic acid supplements, removal of the spleen, or a blood and bone marrow stem cell transplant

In vivo time-gated diffuse correlation spectroscopy at quasi-null source-detector separation