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Animal research also supports the use of crocin in COPD: In one study that used an animal model of COPD, crocin decreased the number of immune cells and infiltration in the lungs, reduced levels of inflammatory cytokines in the lungs and brain, and decreased signs of depression, such as weight loss, appetite, and periods of immobility during physical tests (Xie 2019)

For apical to basolateral (AB) and basolateral to apical (BA) permeability, compounds were added at 10 M concentration to the apical (A) side and basolateral (B) side, respectively, and the corresponding amount of permeation was determined by measuring compound concentration on the B or A side

Thus for drugs known to undergo enterohepatic recirculation, the need for therapeutic drug monitoring may be necessary to ensure optimal dosing and to avoid adverse effects

3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel anti-glioma effects