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For example, someone with cardiovascular symptoms wouldnt meet the criteria unless they also had gastrointestinal or dermatological symptoms.[ref] One form of MCAS, now called idiopathic anaphylaxis , involves sudden, often random-seeming episodes of throat swelling, itching, wheezing, shortness of breath, stomach pain, nausea, vomiting, diarrhea, and a drop in blood pressure

Chikweto A, Bhaiyat MI, Sharma R, deAllie C, P.E

Solvent Accessible Surface Area (SASA) The surface area of a biomolecule that is reachable by a solvent is known as the accessible surface area (ASA) or SASA

The metal iron is a direct pro-oxidant metal, and it is involved in the enzymatic catalytic process in the production of ROS