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This work was partially supported by the National Natural Science Foundation (31770796 to Y.J., 81730099 to X.X.), the National Science and Technology Major Project (2018ZX09711002-002-002) to Y.J., the National Key R&D Programs of China (2018YFA0507002), the Shanghai Municipal Science and Technology Major Project (2019SHZDZX02), the CAS Strategic Priority Research Program (XDB37030103) to H.E.X., and the Shanghai Municipal Science and Technology Commission Grant (20S11903200) to X.X

One of the most well-studied products of the methylation cycle, homocysteine, is the common link between methylation and making glutathione, also called the trans-sulfuration pathway

Studies suggest vitamin B6 can reduce inflammation for people with conditions like rheumatioid arthritis