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An increase in growth hormone levels has been associated with improved cell proliferation due to telomere shortening and a reduction in cellular death due to a decline in processes such as oxidative stress

[DOI] [PMC free article] [PubMed] [Google Scholar] 179.Marquis K., Debigare R., Lacasse Y., LeBlanc P., Jobin J., Carrier G., Maltais F

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When GHRP-2 binds to GHSR-1a in the hypothalamus, it is theorized to trigger a signal transduction cascade that could lead to increased production of the hunger-inducing neuropeptide, Neuropeptide Y (NPY), and Agouti-related peptide (AgRP), both of which are believed to play significant roles in energy homeostasis and appetite regulation