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Ecotoxicology 22 , 959973 (2013)

Studies have found that high oxidative stress levels (e.g., increased intracellular superoxide anion, oxidized glutathione, XO activity, etc.) and oxidative damage (e.g., elevated malondialdehyde, 8-oxodeoxyguanosine levels) in leukocytes from aged mice and peripheral blood immune cells from elderly humans are consistent with impaired immune responses

We propose that these terminals may possess independently regulated glycolytic enzymes and mitochondrial networks, allowing them to generate ATP rapidly in response to high-frequency firing without solely depending on axonal transport from the cell body

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