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First of all, GSSG may activate the SAPK/MAPK pathway, leading to cell apoptosis

doi: 10.3389/fmicb.2022.798853 122 ThanabalasuriarAScottBNVPeiselerMWillsonMEZengZWarrenerPet al

Furthermore, oncogenes are originally believed to elevate the ROS levels in cells, supported by the facts that ectopic expression of different oncogenes (e.g., Myc and KRAS) increase ROS levels in cells [6, 7]