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Secretions from the harderian gland, found in the orbit of some rodents and thought to be an accessory to the lachrymal gland in some species, inhibit aggression and appear to induce appeasement in blind mole-rats (Shanas & Terkel, Reference Shanas and Terkel1997)

Long-term safety, efficacy, and patient-specific responses should be key focuses of future investigations

These approaches are subject to many of the same limitations as nutritional/microbiota therapies for TBI, including the lack of a suitable animal model of the human microbiome, heterogeneity in the methods/quality of microbiome data collection, the protracted timeline and inevitable presence of confounding variables in human diet trials [130]

Inhibition of DNA methyltransferases blocks mutant huntingtin-induced neurotoxicity