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Examining the references of important studies, we also identified potentially relevant citations not recovered by the initial literature searches

Oxygen and carbon dioxide were measured in the sealed treadmill chamber every 15 s

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We conclude that while recent evidence suggests that the effect of hypoxia on ROS production is highly dependent on the cell type and the duration of exposure, efforts should be made to conduct experiments under carefully controlled, physiological microenvironmental conditions in order to rule out potential artifacts and improve reproducibility in research