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These may include: Smoking or being exposed to second-hand smoke Exposure to dusts, fumes or chemicals in the workplace Indoor air pollution from sources like burning fuel for heat or coal to cook Asthma in childhood Early life events, including poor growth in utero, prematurity or frequent respiratory infections A rare genetic condition called alpha-1 antitrypsin deficiency Who is at risk of developing COPD

Arch Biochem Biophys 83(2):528537

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By the end of the 2000s, the industry was subject to state investigations, court actions, fines and much negative publicity