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The answer involves MTHFR mutations

doi: 10.1038/s41584-022-00793-5 11 HasegawaTKikutaJSudoTMatsuuraYMatsuiTSimmonsSet al

The condition affects the tendons that anchor the forearm's wrist-extensor/flexor muscles to a bony bump on the outer/inner elbow called the lateral/medial epicondyle