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The limitations of the study are that the sample size is not very large, the supplementation doses used are not known (although the frequency is), the length of time the participants had been following a vegetarian diet is not known, and there were many more supplement users (75%) than

We noticed the downregulation of CREB1 (FC 0.92), a downstream target of PKA signaling pathway 32 , and synaptophysin (FC 1.09), a SV-associated protein important for synaptic trafficking and neurotransmitter release 33

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