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This observation, combined with evidence that older adults have blunted MOTS-c responses to exercise, supports the hypothesis that declining mitochondrial peptide signaling contributes to the reduced exercise adaptability seen in aging

To confirm that the cellular proliferation induced by the dimeric macrocycles involved the promotion of DNA synthesis in response to Met signalling, we monitored DNA synthesis in normal HPAEC (human pulmonary artery endothelial cells)

Also, reference memories were evaluated by measuring the number of times each animal crossed over a reference point, where the platforms were kept during training phase after the animals were placed on a novel place in the quadrant

GLP-1: Glucagon-like peptide-1