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Contributes to the macronutrient metabolism

The diagnostic approach, therefore, should follow the path of those neurodegenerative diseases, like Alzheimers disease (AD) for example, and less of toward disease with simple diagnostic cut-off using blood-based biomarker, such as diabetes mellitus, wherein diagnostic confirmation, monitoring treatment response, as well as prognostication can be done using a clear cut-off point of plasma glucose levels

Deficiency develops gradually, as the body stores approximately 2-5 mg of B12 in the liver, which can sustain normal function for several years even with inadequate intake or absorption

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