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Effect of semaglutide was weaker than that of tirzepatide

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Except for the EMs group ( n = 10), the three other groups were intraperitoneally injected with iron dextran (250 g/g, Shanghai Yuanye Bio-Technology Co., Ltd, China, #9004-66-4) every 2 days for 3 consecutive weeks

Semaglutide (Wegovy) FDA-approved for: Chronic weight management Treatment of Metabolic dysfunction-Associated Steatohepatitis (MASH) approved August 2025 FDA-indicated for: Reducing risk of heart attack, stroke, and cardiovascular death in adults with established cardiovascular disease who are obese or overweight Weekly injection Clinical trials show an average weight loss of 1215% of body weight