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Description

Crystallogr 62 , 10021011 (2006)

Elevated levels of cleaved PARP are associated with HSC apoptosis, which can be induced by pharmacological agents such as berberine (BBR) and carvedilol (89,90)

However, an /-fold hydrolase EH subfamily categorizes mEH, sEH, EH3, and EH4 together from the remaining three EHs (which can be categorized separately based on their catalytic mechanism and substrate preferences) ( 4.3.1 sEH Overall, mEH and sEH have received significantly more attention than EPHX3/4 and thus, their functions are better understood