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Moreover, ammonium accumulation alters the metabolic state of immune cells, further weakening their anti-tumor responses (113)

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As numerous studies demonstrated the ineffectiveness of L-arginine supplementation on increasing NO synthesis, researchers have begun to explore the potential therapeutic benefits of L-citrulline

On a related note, the antigen to be neutralized needs to mimic the in vivo counterpart as much as possible, since glycosylations and processing are of critical importance to the function and stability of the protein