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In: StatPearls

In clinical trials, testing Romidepsin (FR901228, an HDAC inhibitor) exhibited failure in treating patients with GBMs (NCT00085540) (24)

While this process is largely viewed as prooxidative, selective expression of antioxidants is an important to prevent chronic inflammation

321,336 Altered phosphorylation of insulin receptor substrate proteins, particularly IRS-1 and IRS-2, is implicated in neuronal insulin resistance, 20,337 which impairs insulins neurotrophic effects, leading to reduced neurite outgrowth and increased vulnerability to injury