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Abstract The endothelial glycocalyx is a dynamic brush-like layer composed of proteoglycans and glycosaminoglycans, including heparan sulfate (HS) and hyaluronic acid (HA), and is an important regulator of vascular homeostasis

By reducing the anionic surface charge of the endothelial glycocalyx, MPO facilitates neutrophil recruitment to sites of infection/inflammation, independent of its classic catalytic function [313]

The 3D structure of the GPx3 mutant with all Cys converted to Ser was refined by MD simulations and analyzed with Profile-3D and Procheck following the method as described previously 31,32