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doi:10.1182/blood-2003-03-0672

Remarkably, as seen in Fig 6D, the HP-INHIB-4488 inhibitor led to up-regulation of proinflammatory genes over the reference control, specifically at the basal (nonstarved) conditions and at 4 and 24 h of starvation, whereas the expression of ER stressassociated genes was up-regulated mostly at 24 h

The lethal dose threshold (LD1) was never achieved in animal safety studies meaning researchers could not identify a dose lethal to 1% of test subjects