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10.1146/annurev.bi.53.070184.003441 34 ForslundC.AspenbergP

To date, no tailored targeting agent has been developed for LCC owing to its lack of consistent genetic alterations

Cuprizone-induced demyelination is not lymphocyte-dependent and occurs even in lymphocyte-deficient recombination activating gene (Rag) knockout mice (Hiremath, 2008)