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IGF-1 and its receptor are preferentially expressed in DRG neurons harvested from sciatic nerve axotomy and streptozotocin (STZ) induced painful neuropathy in diabetes[57]

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Thiol-dependent enzymes and their inhibitors: a review

PPP, pentose phosphate pathway

Overall, while some evidence supports macas potential benefits, the data remains limited, and more thorough research is needed to draw reliable conclusions