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This therefore could mean our understanding of mitochondrial toxicity and insulin resistance is limited A further conflict is supported by the fact that some antidiabetic drugs such as biguanides and thiazolidinediones are known inhibitors of mitochondrial complex I and II, however, these are conventional insulin sensitizers used in clinical settings to date

Simabuco FM, et al

Nie C, He T, Zhang W, Zhang G, Ma X (2018) Branched chain amino acids: beyond nutrition metabolism

An increase in telomere signals in the nucleus is caused by insufficient chromatin condensation as a result of the changed chromatin architecture