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Thus, CD38 plays a beneficial role in the recovery of CHI of mice, and this effect is mediated, at least in part, by an increase in the number of microglia/macrophages, mediated by CD38 ( Effect of CD38 on Macrophage Function and Its Possible Mechanisms Effect of CD38 on the Intracellular Calcium Concentration of Macrophages CD38 is a regulator of the intracellular calcium pool and has the characteristics of anti-osteoclastogenesis

Several visual system disorders cause functional and structural alterations in RGCs (i.e., DR, glaucoma, demyelinating optic neuritis, and ischemic optic neuritis) (184)

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The underlying mechanism involves the suppression of the NF-B signaling pathway, which plays a crucial role in inflammation and keratinocyte proliferation associated with PsO