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Classified by their potential biological functions, these genes include heat shock proteins, heat shock transcription factors, mediators for calcium signal transduction, such as calmodulin, important signaling enzyme protein tyrosine phosphatases (PTPs), a blue copper-binding protein which is an essential catalyst for redox reactions, a mitochondrial uncoupling protein, pyruvate decarboxylase, and a myb-related transcription factor

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Due to the requirement for biodegradability (in the context of the prevention of long-term toxicity of nanoparticles) silica, sulfide or phosphate nanoparticles can be used