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Excessive doses can leads to potential risks such as inhibition of breast milk production

Patients who experience a persistent sensation of tightness at the oral commissure and who present with distortion or retraction of the oral commissure, difficulty controlling a food bolus with chewing or frequent biting of the cheek during chewing, may be considered optimal candidates for botulinum toxin injection into this muscle

bioRxiv: preprint Server Biol

Another aspect of the invention pertains to treating obesity or related chronic metabolic condition by administering a therapeutically effective amount of one or more cations of the invention followed by administration of one or more cations chosen from Tables 3a and 3b