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The VASs were administered 1 h before and 0, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 6, 7, 8, 9, 10, 11, 12, and 24 h after drug administration

9,10 Sustained intakes above this can cause selenosis, with symptoms including hair loss, brittle nails, a garlic odour on the breath, digestive upset, and, at high levels, nerve problems

However, these regimens have shortcomings like medication associated issues (susceptibility to infections, liver problems, bone density loss, and allergic reactions), limited efficacy (frequent flare-ups), biologic therapy risks (infusion reactions, may reduce the effectiveness of antibodies), surgery considerations (may cause potential complications), cost and accessibility (biologics and JAK inhibitors), psychological impact etc

Simultaneously, MPs/NPs impair lysosomal degradation pathways, exacerbating intraneuronal -synuclein accumulation and promoting the formation of Lewy bodies