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doi: 10.1016/j.cmet.2018.12.003 77 NackiewiczDDanMSpeckMChowSZChenYCPospisilikJAet al

Lipid peroxidation drives liquid-liquid phase separation and disrupts raft protein partitioning in biological membranes

Previously, BPC 157 as an originally anti-ulcer peptide was implemented in inflammatory bowel disease trials [1015], and now multiple sclerosis [16], lethal dose (LD1) could be not achieved [1016]

The underlying mechanism of this impaired engulfment is linked to the disruption of the Rho GTPase signaling, which is crucial for phagocytosis by pyocyanin-generated ROS (108, 136)