The increased entry of calcium ions (Ca2+) into mitochondria can lead to ROS generation and depolarization of the mitochondrial membrane, all occurring without ATP synthesis (Susin et al., 1998
Combined interleukin-3/chemotherapy treatment of acute myeloblastic leukemia: in vivo and in vitro studies
The involvement of oxidative stress mechanisms have also been suggested in some psychiatric illnesses, including depression, anxiety disorders, schizophrenia, and autism spectrum disorders (Valko et al., 2007
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