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Description

Chen found in human melanoma cells that silencing iPLA2 would enhance the sensitivity to p53-mediated ferroptosis without significant effects on cells that usually express iPLA2, suggesting that iPLA2 can inhibit p53-mediated ferroptosis, and p53-driven ferroptosis is independent of GPX4 [41]

Using label-free quantification or isotope-based approaches (e.g., TMT, SILAC, or spiked internal standards), we can compare modification intensities and generate fold-change data