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It makes up 50-70% of silymarins structure and may have the best radical-scavenging potential of all the constituent flavonoids.11 14 In the supplements space, "milk thistle" and "silymarin" are often interchangeable terms, as silymarin is the key player behind milk thistle's purported health benefits

For instance, microglia can activate astrocytes into a neurotoxic state by releasing mitochondrial fragments and damaged mitochondria, further mediating extracellular neuronal death in neuroinflammation (23)

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The key is to use the lowest effective volume and frequency to correct the deficiency or meet the metabolic need, and to adjust as the patients condition improves