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All statistical analyses were conducted using GraphPad Prism 8 software

Le Rhun E, Preusser M, Roth P, Reardon DA, van den Bent M, Wen P, et al

Pellets were grinded with pestles in 100 l of the same buffer, cells were lysed by two freeze-thaw cycles and insoluble material was removed by filtration in a COSTAR R Spin-X centrifuge tube filter