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A 2025 cell line study replicated the telomere-lengthening finding and proposed that epithalon may also activate ALT (Alternative Lengthening of Telomeres) pathways in addition to direct telomerase upregulation

FIGURE 1 3.2 FOXO4-DRI effectively improves vascular function in prematurely aging mice To further explore the role of FOXO4-DRI in aged mice, we constructed prematurely aging mouse model by administering D-galactose (200 mg/kg) intraperitoneally for 8 weeks