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10.2165/00003088-197702050-00001 85 MajdaK.Kaufman-SzymczykA.Lubecka-PietruszewskaK.BednarekA.Fabianowska-MajewskaK

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However, there have also been cases of people having mood symptoms while on isotretinoin that improved when they stopped treatment and returned when they restarted it, suggesting that this drug can, in rare instances, cause meaningful mood changes

Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: Identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3