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This distinction in transcriptional regulation, and the absence of a change to MT1 and MT2, suggests that decreased MT3 levels may not necessarily be a direct regulatory result of decreased copper levels but reflect parallel disease processes or broader copper dysregulation previously reported in the human ALS and MS spinal cord 15,16

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The PubMed search also revealed that the pioneering use of transferrin receptor ligands for brain-targeting nanoparticle drug delivery systems was reported in 1996 by Huwyler et al

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