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According to the described pro-oxidative effect of UV radiation, as well as relevance of effective stimulation of the antioxidant and antiapoptotic system, the aim of this study was to investigate the combined effect of ascorbic acid and rutin on redox homeostasis, lipid and protein oxidative modifications, and apoptosis of human skin cells (keratinocytes and fibroblasts) after UVA and UVB irradiation