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Figure 2 Redox balance and ROS production are important mediators of insulin signaling (102)

Beyond mRNA, RNA interferences (RNAi) platforms (siRNAs, miRNA, and lncRNA-coding RNAs) enable sequence specific silencing of aberrant genes (Friedrich and Aigner, 2022

More critically, upon penetrating the BBB, ROS directly damage neurons and glial cells

It is well established that iron overload and more generally ferroptosis can trigger macrophage polarization, increasing M1-like markers such as IL-6, IL-1, and TNF, while decreasing M2-like markers [25, 26]