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Other adjustment methods less affected by inter-individual variability introduced by muscle mass, diet, health and physical activity, like specific gravity or osmolality, are preferred to adjust for urinary dilutions in observational studies targeting a population

Calcium activates proteases that convert XDH to XO, disrupts mitochondrial function leading to increased electron leakage, and can activate other ROS-producing enzymes (Huang et al., 2020)

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